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[16] Reported rates from trials include: Nausea: ~44% Vomiting: ~25% Diarrhea: ~31% Constipation: ~23% Dyspepsia: ~10% These effects reflect slowed gastric motility and are usually mild, but can lead to clinical implications: Dehydration Electrolyte abnormalities ED presentations for poor oral intake

A previous study also found that GLP1 may stimulate the secretion of insulin in cells and induce glucose catabolism via the mTOR-dependent HIF-1 activation pathway (Figure 2) [92]

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